Contact dermatitis is an inflammatory eczematous skin disease. It is caused by chemicals or metal ions that exert toxic effects without inducing a T-cell response (contact irritants) or by small reactive chemicals that modify proteins and induce innate and adaptive immune responses (contact allergens).
Is contact dermatitis A inflammatory skin disease?
Contact dermatitis (CD) is an inflammatory skin disease caused by chemicals or metal ions that exert irritant (toxic) effects, or by small reactive chemicals (contact allergens) that modify proteins and induce immune responses (predominantly by T-cell response) (1).
What type of disease is contact dermatitis?
Contact dermatitis is a red, itchy rash caused by direct contact with a substance or an allergic reaction to it. The rash isn’t contagious or life-threatening, but it can be very uncomfortable. Many substances can cause such reactions, including soaps, cosmetics, fragrances, jewelry and plants.
Is atopic dermatitis a chronic inflammatory disease?
Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders.
Is dermatitis an autoimmune disease?
For the first time, a team led by researchers at the Icahn School of Medicine at Mount Sinai has proven that atopic dermatitis, also known as eczema, is an immune-driven (autoimmune) disease.
When should you refer to contact dermatitis?
When to see a GP
A GP may refer you to a doctor who specialises in treating skin conditions (dermatologist) for further tests if: the substance causing your contact dermatitis cannot be identified. your symptoms are not responding to treatment.
What is the most common cause of contact dermatitis?
Nickel. Nickel is the most frequent cause of allergic contact dermatitis.
What autoimmune disease causes rash?
Lupus is the autoimmune disease that is most likely to cause a sun-related rash. Up to 70% of lupus cases are worsened by sun exposure or extended time under fluorescent lights, a condition known as “photosensitivity.” Many lupus-related rashes appear on areas of the skin most heavily exposed to sunlight.
What is the main cause of dermatitis?
A common cause of dermatitis is contact with something that irritates your skin or triggers an allergic reaction — for example, poison ivy, perfume, lotion and jewelry containing nickel.
Does dermatitis cause inflammation?
Dermatitis is a general term for conditions that cause inflammation of the skin.
What is inflammatory skin disease?
What is an inflammatory skin disease? Inflammatory skin diseases are characterised by the activation of the innate and adaptive immune system via the production of pro-inflammatory cytokines . They are classified as autoimmune diseases and autoinflammatory syndromes or diseases.
What is the most common inflammatory skin disease?
Atopic dermatitis (AD) and psoriasis (PS) are the most common chronic inflammatory diseases of the skin.
Which immune mechanism is involved in contact dermatitis?
Allergic contact dermatitis is a classic example of a cell mediated hypersensitivity reaction in the skin. This occurs as a result of xenobiotic chemicals penetrating into the skin, chemically reacting with self proteins, eventually resulting in a hapten-specific immune response.
What autoimmune disease is associated with eczema?
Some primary immunodeficiency diseases are, however, associated with more severe eczema. These include WAS, Hyper-IgE Syndrome (HIES), IPEX syndrome, and certain forms of Severe Combined Immune Deficiency (SCID).
What are autoimmune diseases caused by?
When the body senses danger from a virus or infection, the immune system kicks into gear and attacks it. This is called an immune response. Sometimes, healthy cells and tissues are caught up in this response, resulting in autoimmune disease.